Problem to be solved: To provide a novel nitrogen monoxide production inhibitor and an application thereof as an anti-inflammatory agent.
Solution: The technical features of the invention designed to solve the above problem are as follows:
(1) An anti-inflammatory agent containing sakura extract as an active component.
(2) A nitrogen monoxide production inhibitor containing sakura extract as an active component.
(3) An agent described in (1) or (2) above, wherein the sakura extract is obtained from the blossoms of the cherry tree.
(4) A nitrogen monoxide production inhibitor containing caffeoyl glucose as an active component.
AGE Production Inhibitor
Product name
Sakura Extract
Title of invention
AGE production inhibitor
Patent number
5792844
Date of filing
February 7, 2014
Date of grant
August 14, 2015
Summary
Problem to be solved: To provide an AGE production inhibitor, or similar, that inhibits production of advanced glycation end product (AGE) with improved biological safety.
Solution: The AGE production inhibitor, or similar, contains at least one chemical compound selected from the following as an active component: 1-O-(E)-caffeoyl-β-D-glucopyranoside, 1-O-(E)-coumaroyl-β-D-glucopyranoside, 1-O-(E)-cinnamoyl-β-D-glucopyranoside, kaempferol 3-O-β-D-glucopyranoside, quercetin 3-O-β-D-glucopyranoside, kaempferol 3-O-(6""-malonyl)-β-D-glucopyranoside, and quercetin 3-O-(6""-malonyl)-β-D-glucopyranoside.
AGE Production Inhibitor
Product name
Sakura Extract
Title of invention
AGE production inhibitor
Patent number
5878023
Date of filing
February 10, 2011
Date of grant
February 5, 2016
Summary
Provided is an AGE production inhibitor, or similar, that inhibits production of advanced glycation end product (AGE) with improved biological safety. The AGE production inhibitor, or similar, contains, as an active component, sakura extract (preferably obtained from the blossoms or the leaves) and/or a processed product thereof. The AGE production inhibitor, or similar, contains at least one chemical compound selected from the following as an active component: 1-O-(E)-caffeoyl-β-D-glucopyranoside, 1-O-(E)-coumaroyl-β-D-glucopyranoside, 1-O-(E)-cinnamoyl-β-D-glucopyranoside, kaempferol 3-O-β-D-glucopyranoside, quercetin 3-O-β-D-glucopyranoside, kaempferol 3-O-(6"-malonyl)-β-D-glucopyranoside, and quercetin 3-O-(6"-malonyl)-β-D-glucopyranoside.
Methods for Inhibiting Advanced Glycation end Product Production, Inhibiting Fibroblast Apoptosis, and/or Promoting Human Fibroblast-Collagen Grating Formulation Using Cherry Blossom and Cherry Leaf Extract
Product name
Sakura Extract
Title of invention
Methods for inhibiting advanced glycation end product production, inhibiting fibroblast apoptosis, and/or promoting human fibroblast-collagen grating formulation using cherry blossom and cherry leaf extract
Patent number
US9381223
Date of filing
February 10, 2011
Date of grant
July 5, 2016
Summary
Disclosed is an AGE production inhibitor or the like, which effectively inhibits the production of an advanced glycation end product (AGE), while having improved biological safety. Specifically disclosed is an AGE production inhibitor or the like, which contains en extract of cherry tree (preferably blossoms or leaves thereof) and/or a processed product of the extract as an active substance. The AGE production inhibitor or the like contains, as an active substance, at least one compound that is selected from among 1-O-(E)-Caffeoyl-β-D-glucopyranoside, 1-O-(E)-Coumaroyl-β-D-glucopyranoside, 1-O-(E)-Cinnamoyl-β-D-glucopyranoside, Kaempferol 3-O-β-D-glucopyranoside, Quercetin 3-O-β-D-glucopyranoside, Kaempferol 3-O-(6″-malony)-β-D-glucopyranoside, and Quercetin 3-O-(6″-malony)-β-D-glucopyranoside.
AGE Production Inhibitor
Product name
Sakura Extract
Title of invention
AGE production inhibitor
Patent number
MY-173496-A
Date of filing
February 10, 2011
Date of grant
January 29, 2020
Summary
Disclosed is an AGE production inhibitor or the like, which effectively inhibits the production of an advanced glycation end product (AGE), while having improved biological safety. Specifically disclosed is an AGE production inhibitor or the like, which contains an extract of cherry (preferably blossoms or leaves thereof) and/or a processed product of the extract as an active ingredient. The AGE production inhibitor or the like contains, as an active ingredient, at least one compound that is selected from the group consisting of 1-O-(E)-caffeoyl-β-D-glucopyranoside, 1-O-(E)-coumaroyl-β-D-glucopyranoside, 1-O-(E)-cinnamoyl-β-D-glucopyranoside, kaempferol 3-O-β-D-glucopyranoside, quercetin 3-O-β-D-glucopyranoside, kaempferol 3-O-(6"-malonyl)-β-D-glucopyranoside, and quercetin 3-O-(7"-malonyl)-β-D-glucopyranoside.
AGE Production Inhibitor
Product name
Sakura Extract
Title of invention
AGE production inhibitor
Patent number
CN102883733
Date of filing
February 10, 2011
Date of grant
August 13, 2014
Summary
Provided is an AGE production inhibitor, or similar, which effectively inhibits the production of advanced glycation end product (AGE) with improved biological safety. The AGE production inhibitor, or similar, contains, as an active component, cherry tree extract (preferably obtained from the blossoms or leaves) and/or a processed product thereof. The AGE production inhibitor, or similar, contains at least one chemical compound selected from the following as an active component: 1-O-(E)-caffeoyl-β-D-glucopyranoside, 1-O-(E)-coumaroyl-β-D-glucopyranoside, 1-O-(E)-cinnamoyl-β-D-glucopyranoside, kaempferol 3-O-β-D-glucopyranoside, quercetin 3-O-β-D-glucopyranoside, kaempferol 3-O-(6"-malonyl)-β-D-glucopyranoside, and quercetin 3-O-(6"-malonyl)-β-D-glucopyranoside.
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