Problem to be solved: To provide a novel tight junction formation accelerator.
Solution: The features of the invention are as follows:
(1) A tight junction formation accelerator that contains bird’s nest extract as an active component.
(2) A claudin-1 protein expression promoter that contains bird’s nest extract as an active component.
(3) A claudin-1 gene expression promoter that contains bird’s nest extract as an active component.
(4) A claudin-4 protein expression promoter that contains bird’s nest extract as an active component.
(5) A claudin-4 gene expression promoter that contains bird’s nest extract as an active component.